Afterload and diastolic function determine right ventricular wall stress, which leads to right ventricular dyssynchrony in patients with pulmonary arterial hypertension.
What are the determinants of right ventricular wall stress and dyssynchrony in patients with pulmonary arterial hypertension?
In patients with pulmonary arterial hypertension, afterload and diastolic function are key determinants of wall stress, which subsequently leads to right ventricular dyssynchrony.
Right ventricular (RV) dyssynchrony has been related to outcome in pulmonary arterial hypertension. Prospectively, we performed echocardiography with measurement of right ventricular dyssynchrony and pressure-volume loop catheterization in 27 pulmonary arterial hypertension patients. Afterload and diastolic function emerged as determinates of wall stress, which results in dyssynchrony.
Richter et al. (2020) studied this question. Afterload and diastolic function determine right ventricular wall stress, which leads to right ventricular dyssynchrony in patients with pulmonary arterial hypertension.