Key result
Higher RV end-systolic wall stress is linked to greater RV dyssynchrony in severe PAH.
Why the study?
Right ventricular dyssynchrony has been related to outcome in pulmonary arterial hypertension, but its relationship to load-independent right ventricular function and wall stress required investigation.
What are the determinants of right ventricular wall stress and dyssynchrony in patients with pulmonary arterial hypertension?
Cross-Sectional (n=27)
What are the determinants of right ventricular wall stress and dyssynchrony in patients with pulmonary arterial hypertension?
In patients with pulmonary arterial hypertension, afterload and diastolic function are key determinants of wall stress, which subsequently leads to right ventricular dyssynchrony.
Answers are grounded in this paper and cite their sources.
RV wall stress may drive dyssynchrony in severe PAH; hypothesis-generating and requires prospective validation before clinical adoption.
Right ventricular (RV) dyssynchrony has been related to outcome in pulmonary arterial hypertension. Prospectively, we performed echocardiography with measurement of right ventricular dyssynchrony and pressure-volume loop catheterization in 27 pulmonary arterial hypertension patients. Afterload and diastolic function emerged as determinates of wall stress, which results in dyssynchrony.
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Richter et al. (2020) conducted a cross-sectional in Pulmonary arterial hypertension (n=27). Right ventricular end-systolic wall stress was evaluated on Association between right ventricular end-systolic wall stress and right ventricular dyssynchrony (unstandardized B coefficient 0.15, 95% CI 0.01 to 0.30, p=0.040). In patients with severe pulmonary arterial hypertension, right ventricular end-systolic wall stress emerged as a significant determinant of right ventricular dyssynchrony.
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