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June 27, 2026World Journal of OncologyOpen Access

Integrated Transcriptomic Analysis Identifies Potential Biomarkers in Castration-Resistant Prostate Cancer

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Authors

ANAbdulghani A NaeemSASaud A AbdulsamadAHAteequllah Hayat

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Overview

Randomized trial identifies biomarkers and therapeutic targets in castration-resistant prostate cancer, suggesting new treatment strategies.

Key Points

  • This research aims to uncover the transcriptional programs in castration-resistant prostate cancer (CRPC) to identify biomarkers and targets for therapy.
  • RNA sequencing–based transcriptomic profiling contrasting PNT2 and 22Rv1 models
  • Differential gene expression analysis using DESeq2
  • Clinical validation using GEPIA2 with datasets from TCGA and GTEx.
  • Significant dysregulation of genes MALAT1, FASN, PARP1, SET, ENSG00000214719, and IGF1 detected.
  • Activation of processes related to metabolism, ribosome function, and PI3K–Akt signaling observed.
  • Increased expression confirmed for FASN, PARP1, SET, and ENSG00000214719 in prostate adenocarcinoma samples.

Cite This Study

Naeem et al. (2026) studied this question.

synapsesocial.com/papers/6a3f6972aea7db3c19540339https://doi.org/10.14740/wjon2772
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Dissecting metastatic castration-resistant prostate cancer using regulatory network analysis of tumor transcriptomes.2026
  2. 2Abstract 6284: Multimoics reveal aberrant pathways and regulation of castration resistant and metastatic prostate cancer2024
  3. 3Molecular landscape for risk prediction and personalized therapeutics of castration-resistant prostate cancer: at a glance2024
  4. 4Androgen receptor reactivation in castration-resistant prostate cancer: mechanisms, epigenetic adaptation, and therapeutic vulnerabilities2026
  5. 5Patient-derived castration-resistant prostate cancer model revealed CTBP2 upregulation mediated by OCT1 and androgen receptor2024 · 7 citations