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May 25, 2026Frontiers in OncologyOpen Access

Androgen receptor reactivation in castration-resistant prostate cancer: mechanisms, epigenetic adaptation, and therapeutic vulnerabilities

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Authors

JGJuntao GuoKWKe WuZMZheng Ma

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Overview

Randomized trial explores AR reactivation strategies in CRPC, suggesting new therapeutic avenues.

Key Points

  • The aim is to understand how androgen receptor reactivation occurs in CRPC and to identify potential therapeutic vulnerabilities.
  • Literature review of mechanisms driving androgen receptor reactivation.
  • Analysis of chromatin changes influencing AR-dependent transcription.
  • Discussion of therapeutic strategies targeting identified vulnerabilities.
  • AR reactivation mechanisms include AR amplification and mutations, leading to persistent signaling.
  • Epigenetic changes contribute to tumor heterogeneity and aggressive phenotypes.
  • Targeted therapies such as PARP inhibitors and AR degraders show promise in overcoming resistance.

Cite This Study

Guo et al. (2026) studied this question.

synapsesocial.com/papers/6a13e67d0e02ee3982d31771https://doi.org/10.3389/fonc.2026.1837998
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