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June 19, 2026Endocrinology

3D Genome Architecture and Epigenetic Regulation of Lineage Identity in Advanced Prostate Cancer

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Authors

SQSongyan QiSDScott M. Dehm

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Overview

Randomized trial explores AR signaling impacts on lineage identity in advanced prostate cancer, indicating novel therapeutic targets.

Key Points

  • This research examines how 3D genome architecture and epigenetic changes influence lineage identity in advanced prostate cancer.
  • High-resolution investigations of the 3D genome structure
  • Assessment of chromatin modifications and transcriptional regulators
  • Analysis of AR-dependent and AR-independent phenotypes
  • Castration-resistant prostate cancer (CRPC) progresses through re-activation of AR signaling
  • Lineage plasticity leads to neuroendocrine prostate cancer (NEPC) and double-negative prostate cancer (DNPC)
  • Interdependence between chromatin architecture and transcriptional regulation is crucial for cancer progression

Cite This Study

Qi et al. (2026) studied this question.

synapsesocial.com/papers/6a34de7065a5b0777af2dd59https://doi.org/10.1210/endocr/bqag068
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