Key points are not available for this paper at this time.
Abstract Transition metal-catalyzed enantioselective Sonogashira-type oxidative C( sp 3 )—C( sp ) coupling of unactivated C( sp 3 )−H bonds with terminal alkynes has remained a prominent challenge. The difficulties mainly stem from the regiocontrol in unactivated C( sp 3 )—H bond functionalization and the inhibition of readily occurring Glaser homocoupling of terminal alkynes. Here, we report a copper/chiral cinchona alkaloid-based N,N,P -ligand catalyst for asymmetric oxidative cross-coupling of unactivated C( sp 3 )—H bonds with terminal alkynes in a highly regio-, chemo-, and enantioselective manner. The use of N -fluoroamide as a mild oxidant is essential to site-selectively generate alkyl radical species while efficiently avoiding Glaser homocoupling. This reaction accommodates a range of (hetero)aryl and alkyl alkynes; (hetero)benzylic and propargylic C( sp 3 )−H bonds are all applicable. This process allows expedient access to chiral alkynyl amides/aldehydes. More importantly, it also provides a versatile tool for the construction of chiral C( sp 3 )—C( sp ), C( sp 3 )—C( sp 2 ), and C( sp 3 )—C( sp 3 ) bonds when allied with follow-up transformations.
Zhang et al. (Thu,) studied this question.