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July 5, 2026PLoS Biology0 citationsOpen Access

The cell cloud: Adopting systems biology concepts in the era of single-cell immunology

TSTal ShayCBChristophe BenoıstRGRicardo Grieshaber‐Bouyer

Key Points

  • This research aims to introduce the 'cell cloud' model for analyzing single-cell data, addressing challenges in biological classification.
  • Utilized high-throughput single-cell assays to gather extensive data.
  • Developed the 'cell cloud' model based on systems biology principles.
  • The model enhances understanding of biological variability in single-cell contexts.
  • Data analysis supports addressing the limitations of discrete categorization in single-cell immunology.

Abstract

High-throughput single-cell assays reveal data that defies discrete categorization. The 'cell cloud' model, grounded in established systems biology principles, offers a framework to navigate biological plasticity alongside technical variability.

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Cite This Study

Shay et al. (2026) studied this question.

synapsesocial.com/papers/6a49f3b0f5d1d45b287ffa84https://doi.org/10.1371/journal.pbio.3003853
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