Pulsed field ablation is increasingly associated with clinical coronary artery spasm, a phenomenon now widely accepted as a class effect.
Case Report
Highlights the risk of clinical coronary artery spasm as a potential class effect complication of pulsed field ablation.
Ablation with pulsed field (PF) energy generates irreversible electroporation in cardiac myocytes, inducing apoptosis and death, with resultant scar and electrophysiological block. The uptake of PF energy in catheter ablation continues to rapidly grow world-wide. Though PF was initially suspected to have fewer complications due to being more cardio-selective than thermal energies, reports of clinical coronary artery spasm have also increased in number, with this phenomenon widely accepted as a class effect1-3.
Mannion et al. (2025) reported a case report. Pulsed field ablation was evaluated. Pulsed field ablation is increasingly associated with clinical coronary artery spasm, a phenomenon now widely accepted as a class effect.