Key result
Pulsed field ablation triggers diffuse multi-coronary artery spasm and cardiac arrest in case report.
Case Report (n=1)
This is the first reported case of remote diffuse coronary artery spasm affecting all coronary vessels and leading to cardiac arrest after pulmonary vein and posterior wall isolation using a focal monopolar pulsed field ablation catheter.
Remote multi-vessel spasm with arrest may occur after monopolar PFA; extends class-effect reports but leaves incidence and prevention open.
Ablation with pulsed field (PF) energy generates irreversible electroporation in cardiac myocytes, inducing apoptosis and death, with resultant scar and electrophysiological block. The uptake of PF energy in catheter ablation continues to rapidly grow world-wide. Though PF was initially suspected to have fewer complications due to being more cardio-selective than thermal energies, reports of clinical coronary artery spasm have also increased in number, with this phenomenon widely accepted as a class effect1-3.
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Mannion et al. (2025) conducted a case report in Recurrent symptomatic atrial fibrillation (n=1). Pulsed field ablation was evaluated on Coronary artery spasm and cardiac arrest. A 64-year-old man experienced diffuse remote multi-coronary artery spasm and cardiac arrest following pulmonary vein and posterior wall isolation using a monopolar pulsed field ablation catheter.
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