Key result
TNF-alpha inhibitors and leadless pacing reverse exercise-induced 2:1 AV block in cardiac sarcoidosis.
Why the study?
Exercise-induced atrioventricular block is an underrecognized early sign of cardiac sarcoidosis.
Case Report (n=1)
Early TNF-alpha inhibitor therapy can reverse refractory high-grade atrioventricular block in cardiac sarcoidosis, and a leadless pacemaker combined with an implantable loop recorder may be a viable individualized strategy for long-term rhythm management.
May prompt sarcoidosis evaluation in exercise-induced AV block; hypothesis-generating for TNF inhibitors and leadless devices pending larger studies.
This case highlights exercise-induced atrioventricular block as an underrecognized early sign of cardiac sarcoidosis.Early targeted therapy with tumor necrosis factor (TNF)-alpha inhibitors can reverse high-grade atrioventricular block refractory to standard immunosuppression.We show the successful use of a leadless pacemaker alongside an implantable loop recorder for long-term rhythm management in cardiac sarcoidosis presenting as lone atrioventricular block, though such strategies must be evaluated on a case-by-case basis through individualized risk stratification
No takes yet. Share an insight, caveat, or question.
Muratas et al. (2026) conducted a case report in Cardiac sarcoidosis with exercise-induced 2:1 atrioventricular block (n=1). TNF-alpha inhibitors, leadless pacemaker, and implantable loop recorder was evaluated on Reversal of high-grade atrioventricular block and long-term rhythm management. TNF-alpha inhibitors and a leadless pacemaker with an implantable loop recorder reversed refractory exercise-induced 2:1 atrioventricular block in a man with cardiac sarcoidosis.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: