Key result
Double P-wave morphology reveals complete Bachmann bundle block in wild-type ATTR amyloidosis.
Why the study?
Atrial involvement in cardiac transthyretin amyloidosis may lead to structural and electrophysiological remodeling that manifests as atrial conduction disorders.
Case Report
Double P-wave morphology on electrocardiogram can indicate complete Bachmann's bundle block due to atrial structural and electrophysiological remodeling in wild-type transthyretin cardiac amyloidosis.
Highlights atrial conduction issues in ATTR amyloidosis; leaves open their prognostic value and management implications.
Cardiac transthyretin amyloidosis (ATTR) is the most common form of cardiac amyloidosis and is caused by age-related deposition of normal transthyretin (TTR), a transport protein for thyroxine and retinol1. Atrial fibrillation (AF) occurs in up to 70% of patients with ATTR amyloidosis during the clinical course of the disease2. Atrial involvement in ATTR amyloidosis may lead to structural and electrophysiological remodeling, which can manifest as atrial conduction disorders.
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Freriks et al. (2026) conducted a case report in Wild-type transthyretin cardiac amyloidosis (ATTR) with complete Bachmann's bundle block. Double P-wave morphology on electrocardiogram was evaluated on Complete Bachmann's bundle block. Double P-wave morphology reveals complete Bachmann's bundle block in wild-type transthyretin amyloidosis, a condition where atrial fibrillation occurs in up to 70% of patients.
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