The synthesis, spectral analysis and biological activities of 4-phenyl-2-hydroxy-chlorosubstituted-2-imino-1,3 thiazines have been carried out. In this case 4-(2'-hydroxy-3',5'-dichlorophenyl)-6-(hexyl)-2-imino-3,6-dihydro-1,3- thiazine (G) has been screened. The compound G was synthesized from 2'-hydroxy-3’,5’-dichlorophenyl-4-(hexyl) chalcone (a”) by the action of thiourea. The compound (a”) was synthesized from 2’-hydroxy-3’,5’-dichloroacetophenone by the action of heptanaldehyde in ethanol and 40% NaOH. The nanoparticles of the compounds G has been prepared by using ultrasonic technique. The newly synthesized titled compound and it’s nanoparticles were screened for their antibacterial activity against some pathogens; Gram+ve bacteria viz. Staphylococcus pneumoniae, Staphylococcus aureus and Gram-ve bacteria viz. Escherichia coli and Pseudomonas fluorescens by using Agar disc diffusion method. All the newly synthesized compounds were found to be active against test pathogens.
*Chhaya D. Badnakhe (Fri,) studied this question.