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The growing demand for advanced neural interfaces that enable precise brain monitoring and modulation has catalyzed significant research into flexible, biocompatible, and highly conductive materials. PEDOT:PSS-based bioelectronic materials exhibit high conductivity, mechanical flexibility, and biocompatibility, making them particularly suitable for integration into neural devices for brain science research. These materials facilitate high-resolution neural activity monitoring and provide precise electrical stimulation across diverse modalities. This review comprehensively examines recent advances in the development of PEDOT:PSS-based bioelectrodes for brain monitoring and modulation, with a focus on strategies to enhance their conductivity, biocompatibility, and long-term stability. Furthermore, it highlights the integration of multifunctional neural interfaces that enable synchronous stimulation-recording architectures, hybrid electro-optical stimulation modalities, and multimodal brain activity monitoring. These integrations enable fundamentally advancing the precision and clinical translatability of brain-computer interfaces. By addressing critical challenges related to efficacy, integration, safety, and clinical translation, this review identifies key opportunities for advancing next-generation neural devices. The insights presented are vital for guiding future research directions in the field and fostering the development of cutting-edge bioelectronic technologies for neuroscience and clinical applications.
Li et al. (Tue,) studied this question.