COVID-19-related myocardial injury can lead to long-term structural and functional changes, including persistent myocardial fibrosis, reduced ejection fraction, and new-onset arrhythmias.
COVID-19 can cause both direct and indirect myocardial injury, potentially leading to long-term structural and functional cardiac consequences.
The mechanisms of coronavirus disease-2019 (COVID-19)-related myocardial injury comprise both direct viral invasion and indirect (hypercoagulability and immune-mediated) cellular injuries. Some patients with COVID-19 cardiac involvement have poor clinical outcomes, with preliminary data suggesting long-term structural and functional changes. These include persistent myocardial fibrosis, edema, and intraventricular thrombi with embolic events, while functionally, the left ventricle is enlarged, with a reduced ejection fraction and new-onset arrhythmias reported in a number of patients. Myocarditis post-COVID-19 vaccination is rare but more common among young male patients. Larger studies, including prospective data from biobanks, will be useful in expanding these early findings and determining their validity.
Siripanthong et al. (Wed,) conducted a review in COVID-19-related myocardial injury. COVID-19 was evaluated. COVID-19-related myocardial injury can lead to long-term structural and functional changes, including persistent myocardial fibrosis, reduced ejection fraction, and new-onset arrhythmias.