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With the global aging population, the impact of aging on various organ systems is becoming increasingly significant. The gastrointestinal tract, a key site of immune activity and microbial colonization, undergoes functional decline that is closely associated with a range of intestinal and systemic diseases. While aging-related fibrosis has been extensively studied in organs such as the lungs, liver, heart, and kidneys, its role in intestinal fibrosis remains underexplored. This review discusses mechanisms by which aging may promote or increase the risk of intestinal fibrosis, including immunosenescence, cellular senescence, gut microbiota dysbiosis, and dysregulated growth factor signaling. Additionally, both traditional and emerging therapeutic strategies are summarized to guide future interventions.
Shi et al. (Sat,) studied this question.