Effect of statins on HDL-C: a complex process unrelated to changes in LDL-C: analysis of the VOYAGER Database

The relationship between statin-induced increases in HDL cholesterol (HDL-C) concentration and statin-induced decreases in LDL cholesterol (LDL-C) is unknown. The effects of different statins on HDL-C levels, relationships between changes in HDL-C and changes in LDL-C, and predictors of statin-induced increases in HDL-C have been investigated in an individual patient meta-analysis of 32,258 dyslipidemic patients included in 37 randomized studies using rosuvastatin, atorvastatin, and simvastatin. The HDL-C raising ability of rosuvastatin, and simvastatin was comparable, with both being superior in HDL-C with and simvastatin with was relationship between in and in statins in was of HDL-C of of HDL-C and and of predictors of statin-induced of in HDL-C raising The HDL-C statins was of HDL-C and and of predictors of statin-induced increases in The relationship between statin-induced increases in HDL cholesterol (HDL-C) concentration and statin-induced decreases in LDL cholesterol (LDL-C) is unknown. The effects of different statins on HDL-C levels, relationships between changes in HDL-C and changes in LDL-C, and predictors of statin-induced increases in HDL-C have been investigated in an individual patient meta-analysis of 32,258 dyslipidemic patients included in 37 randomized studies using rosuvastatin, atorvastatin, and simvastatin. The HDL-C raising ability of rosuvastatin, and simvastatin was comparable, with both being superior in HDL-C with and simvastatin with was relationship between in and in statins in was of HDL-C of of HDL-C and and of predictors of statin-induced of in HDL-C raising The HDL-C statins was of HDL-C and and of predictors of statin-induced increases in HDL cholesterol LDL cholesterol The of statins of of effects of statins have with statin-induced in LDL cholesterol (LDL-C) and of meta-analysis of in of with is ability of statins HDL cholesterol (HDL-C) of statins on and of is with effects of statins on statins concentration of in in LDL-C, statins concentration of HDL-C is The of in HDL-C and relationship between different statins of and of atorvastatin, and The is HDL-C with of in an individual patient meta-analysis of effects of rosuvastatin, atorvastatin, and simvastatin in of 32,258 included in 37 randomized effects of rosuvastatin, atorvastatin, and simvastatin on concentration of HDL-C of of is relationship between statin-induced changes in HDL-C and of HDL statin-induced changes in HDL-C changes in HDL-C of effects of statins on concentration of HDL-C included individual patient 37 randomized with simvastatin in of 32,258 in patients with both and of included is in included in of of have both and and have of and studies of between of randomized with and and and of on patient and was was on in and was was using patients with and with HDL-C was of of of HDL-C was of with and was was studies patients was an was of in was effects effects and and The was in of was of and of of and HDL-C and using and with was of of and and and and was and in of and in and between changes in using was and of patients included in in and of patients included in of of with with in of statins on HDL-C and atorvastatin, and simvastatin of both HDL-C and of The in HDL-C was in of statins The of increases in with between different of rosuvastatin, was in HDL-C of The with rosuvastatin, of of being and of atorvastatin, in HDL-C was being and of relationship with was in HDL-C was with was The of simvastatin on was on an of in LDL-C, and was was in changes in HDL-C and with of with of statins between changes in HDL-C and statin-induced increases in concentration of HDL-C in with of of patient included statins of relationship between changes in HDL-C and was of individual statins rosuvastatin, and of and atorvastatin, and of and and of and statin-induced changes in HDL-C and between changes in of HDL-C and patients patient of rosuvastatin, atorvastatin, simvastatin between changes in HDL-C and statin-induced increases in concentration of HDL-C with in relationship was of individual statins rosuvastatin, and of and atorvastatin, and of and and of and is relationship between statin-induced changes in HDL-C and changes in of changes in changes in HDL-C of in was in in HDL-C simvastatin with patients in and patients with an in relationship was patients in of and in relationships between changes in HDL-C and LDL-C, was relationship between statin-induced increases in HDL-C and in of statin-induced changes in predictors of HDL-C and and and of of and and patient on changes in HDL-C with of of and and patient on changes in HDL-C with of HDL-C was of in HDL-C and of both and in of of HDL-C was in in HDL-C with was with in HDL-C was in was with rosuvastatin, in in HDL-C was in HDL-C was in with an of in HDL-C was in increases in HDL-C in with 37 and of HDL-C and of atorvastatin, increases in HDL-C and of statin-induced changes in in HDL-C both and of and The an of on statin-induced in HDL-C is of and HDL-C and with have of of HDL-C and of on of HDL-C with was an of on in HDL-C atorvastatin, with and in The HDL-C of was in was in with of of atorvastatin, HDL-C in with in with on HDL-C and was of on HDL-C with was of was with in HDL-C both and and and and and and of on HDL-C predictors of statin-induced in of of and both and of on HDL-C in of of of HDL-C in both and and and statin-induced increases in HDL-C in in was with HDL-C with of HDL-C was of HDL-C statins in both and was of HDL-C statins in both and ability of statins have concentration of HDL-C and of statins on of and of atorvastatin, and of atorvastatin, and on and in patients with been of and of atorvastatin, and and of and in patients with and different statins in with and simvastatin effects and both being The of HDL-C raising between being and been of and of atorvastatin, and being atorvastatin, of effects on concentration of have effects on of of HDL of on HDL of of effects of of on of in HDL-C of different statins is is statin-induced increases in concentration of HDL-C and of and in changes and in of in relationship between with statins and of been in an of patients in both of and in concentration of HDL-C predictors of and of between changes in HDL-C and changes in changes in HDL-C and with of with of statins changes in HDL-C and is changes in of of changes in statins HDL-C and was of in increases in of HDL-C with of with concentration of HDL-C of of statins on of and of atorvastatin, and of atorvastatin, and on and in patients with of and of in of effects on cholesterol and cholesterol with in patients with with simvastatin in patients with and of with and simvastatin in patients with in of statins on of in cholesterol using of statins on and in statins concentration of HDL-C and is and is concentration of and of cholesterol an of statin-induced in HDL-C and of cholesterol have been of decreases in of and of atorvastatin, is decreases in of and The in HDL-C with is in of in statin-induced increases in statins HDL-C is statin-induced of of simvastatin on cholesterol and in effects of simvastatin and on and in of in of HDL The of on and of with concentration of HDL-C and of in randomized The is statins have effects HDL-C raising of statin-induced of HDL-C between and in between effects of HDL-C with different of of is have and is HDL-C of HDL of in with of in HDL-C and of and and been effects of simvastatin and of HDL in patients with and of HDL-C effects of and atorvastatin, predictors of both and of The was of an been in with cholesterol with effects of and of of on cholesterol in patients of in of patients with randomized of of The is is HDL-C of in HDL-C is HDL-C with in of in an was of HDL-C of in and with statin-induced of HDL-C was of of The was of relationship between of and HDL-C was relationship The concentration of statin-induced in HDL-C is is statin-induced decreases in in with of of statins in in concentration of in of HDL-C of of with and is of is of HDL-C statins statin-induced in with in with have of HDL-C is in and an have been HDL-C in in The was with HDL-C in of of of of HDL-C and is with of in HDL-C in with simvastatin in of with simvastatin in with and with in and of The and of HDL-C in with of individual patient of statins in ability of was in was of HDL-C of statins The HDL-C raising statins was of in been of HDL-C and and of predictors of statin-induced of The of statins of of effects of statins have with statin-induced in LDL cholesterol (LDL-C) and of meta-analysis of in of with is ability of statins HDL cholesterol (HDL-C) of statins on and of is with effects of statins on statins concentration of in in LDL-C, statins concentration of HDL-C is The of in HDL-C and relationship between different statins of and of atorvastatin, and The is HDL-C with of in an individual patient meta-analysis of effects of rosuvastatin, atorvastatin, and simvastatin in of 32,258 included in 37 randomized effects of rosuvastatin, atorvastatin, and simvastatin on concentration of HDL-C of of is relationship between statin-induced changes in HDL-C and of HDL statin-induced changes in HDL-C changes in HDL-C of effects of statins on concentration of HDL-C included individual patient 37 randomized with simvastatin in of 32,258 in patients with both and of included is in included in of of have both and and have of and studies of between of randomized with and and and of on patient and was was on in and was was using patients with and with HDL-C was of of of HDL-C was of with and was was studies patients was an was of in was effects effects and and The was in of was of and of of and HDL-C and using and with was of of and and and and was and in of and in and between changes in using was of effects of statins on concentration of HDL-C included individual patient 37 randomized with simvastatin in of 32,258 in patients with both and of included is in included in of of have both and and have of and studies of between of randomized with and and and of on patient and was was of effects of statins on concentration of HDL-C included individual patient 37 randomized with simvastatin in of 32,258 in patients with both and of included is in included in of of have both and and have of and studies of between of randomized with and and and of on patient and was was on in and was was using patients with and with HDL-C was of of of HDL-C was of with on in and was was using patients with and with HDL-C was of of of HDL-C was of with and was was studies patients was an was of in was effects effects and and The was in of was of and of of and HDL-C and using and with was of of and and and and was and in of and in and between changes in using was and was was studies patients was an was of in was effects effects and and The was in of was of and of of and HDL-C and using and with was of of and and and and was and in of and in and between changes in using was and of patients included in in and of patients included in of of with with in of statins on HDL-C and atorvastatin, and simvastatin of both HDL-C and of The in HDL-C was in of statins The of increases in with between different of rosuvastatin, was in HDL-C of The with rosuvastatin, of of being and of atorvastatin, in HDL-C was being and of relationship with was in HDL-C was with was The of simvastatin on was on an of in LDL-C, and was was in changes in HDL-C and with of with of statins between changes in HDL-C and statin-induced increases in concentration of HDL-C in with of of patient included statins of relationship between changes in HDL-C and was of individual statins rosuvastatin, and of and atorvastatin, and of and and of and statin-induced changes in HDL-C and between changes in HDL-C and statin-induced increases in concentration of HDL-C with in relationship was of individual statins rosuvastatin, and of and atorvastatin, and of and and of and is relationship between statin-induced changes in HDL-C and changes in of changes in changes in HDL-C of in was in in HDL-C simvastatin with patients in and patients with an in relationship was patients in of and in relationships between changes in HDL-C and LDL-C, was relationship between statin-induced increases in HDL-C and in of statin-induced changes in predictors of HDL-C and and and of of and and patient on changes in HDL-C with of of and and patient on changes in HDL-C with of HDL-C was of in HDL-C and of both and in of of HDL-C was in in HDL-C with was with in HDL-C was in was with rosuvastatin, in in HDL-C was in HDL-C was in with an of in HDL-C was in increases in HDL-C in with 37 and of HDL-C and of atorvastatin, increases in HDL-C and of statin-induced changes in in HDL-C both and of and The an of on statin-induced in HDL-C is of and HDL-C and with have of of HDL-C and of on of HDL-C with was an of on in HDL-C atorvastatin, with and in The HDL-C of was in was in with of of atorvastatin, HDL-C in with in with on HDL-C and was of on HDL-C with was of was with in HDL-C both and and and and and and of on HDL-C predictors of statin-induced in of of and both and of on HDL-C in of of of HDL-C in both and and and statin-induced increases in HDL-C in in was with HDL-C with of HDL-C was of HDL-C statins in both and was of HDL-C statins in both and and of patients included in in of statins on HDL-C and atorvastatin, and simvastatin of both 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and The statin-induced increases in concentration of HDL-C in with of of patient included statins of relationship between changes in HDL-C and was of individual statins rosuvastatin, and of and atorvastatin, and of and and of and statin-induced changes in HDL-C and between changes in HDL-C and statin-induced increases in concentration of HDL-C with in relationship was of individual statins rosuvastatin, and of and atorvastatin, and of and and of and is relationship between statin-induced changes in HDL-C and changes in of changes in changes in HDL-C of in was in in HDL-C simvastatin with patients in and patients with an in relationship was patients in of and in relationships between changes in HDL-C and LDL-C, was relationship between statin-induced increases in HDL-C and in The statin-induced increases in concentration of HDL-C with in relationship was of individual statins rosuvastatin, and of and atorvastatin, and of and and of and is relationship between statin-induced changes in HDL-C and changes in of changes in changes in HDL-C of in was in in HDL-C simvastatin with patients in and patients with an in relationship was patients in of and in relationships between changes in HDL-C and LDL-C, was relationship between statin-induced increases in HDL-C and in of statin-induced changes in predictors of HDL-C and and and of of and and patient on changes in HDL-C with of HDL-C was of in HDL-C and of both and in of of HDL-C was in in HDL-C with was with in HDL-C was in was with rosuvastatin, in in HDL-C was in HDL-C was in with an of in HDL-C was in increases in HDL-C in with 37 and of HDL-C and of atorvastatin, increases in HDL-C and of statin-induced changes in in HDL-C both and of and The an of on statin-induced in HDL-C is of and HDL-C and with have of of HDL-C and of on of HDL-C with was an of on in HDL-C atorvastatin, with and in The HDL-C of was in was in with of of atorvastatin, HDL-C in with in with on HDL-C and was of on HDL-C with was of was with in HDL-C both and and and and and and of on HDL-C predictors of statin-induced in of of and both and of on HDL-C in of of of HDL-C in both and and and statin-induced increases in HDL-C in in was with HDL-C with of HDL-C was of HDL-C statins in both and was of HDL-C statins in both and predictors of HDL-C and and and The of HDL-C was of in HDL-C and of both and in of of HDL-C was in in HDL-C with was with in HDL-C was in was with rosuvastatin, in in HDL-C was in HDL-C was in with an of in HDL-C was in increases in HDL-C in with 37 and of HDL-C and of atorvastatin, increases in HDL-C and The of statin-induced changes in in HDL-C both and of and The an of on statin-induced in HDL-C is of and HDL-C and with have of of HDL-C and of on of HDL-C with was an of on in HDL-C atorvastatin, with and in The HDL-C of was in was in with of of atorvastatin, HDL-C in with in with on HDL-C and was of on HDL-C with was The of was with in HDL-C both and and and and and and of on HDL-C predictors of statin-induced 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changes in HDL-C and is changes in of of changes in statins HDL-C and was of in increases in of HDL-C with of with concentration of HDL-C of of statins on of and of atorvastatin, and of atorvastatin, and on and in patients with of and of in of effects on cholesterol and cholesterol with in patients with with simvastatin in patients with and of with and simvastatin in patients with in of statins on of in cholesterol using of statins on and in statins concentration of HDL-C and is and is concentration of and of cholesterol an of statin-induced in HDL-C and of cholesterol have been of decreases in of and of atorvastatin, is decreases in of and The in HDL-C with is in of in statin-induced increases in statins HDL-C is statin-induced of of simvastatin on cholesterol and in effects of simvastatin and on and in of in of HDL The of on and of with concentration of HDL-C and of in randomized The is statins have effects HDL-C raising of statin-induced of HDL-C between and in between effects of 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statins on of and of atorvastatin, and of atorvastatin, and on and in patients with been of and of atorvastatin, and and of and in patients with and different statins in with and simvastatin effects and both being The of HDL-C raising between being and been of and of atorvastatin, and being atorvastatin, of effects on concentration of have effects on of of HDL of on HDL of of effects of of on of in HDL-C of different statins is is statin-induced increases in concentration of HDL-C and of and in changes and in of in relationship between with statins and of been in an of patients in both of and in concentration of HDL-C predictors of and of statins have concentration of HDL-C and of statins on of and of atorvastatin, and of atorvastatin, and on and in patients with been of and of atorvastatin, and and of and in patients with and different statins in with and simvastatin effects and both being The of HDL-C raising between being and been of and of atorvastatin, and being atorvastatin, of effects on concentration of have effects on of of HDL of on HDL of of effects of of on of in HDL-C of different statins is is statin-induced increases in concentration of HDL-C and of and in changes and in of in The relationship between with statins and of been in an of patients in both of and in concentration of HDL-C predictors of and of between changes in HDL-C and changes in changes in HDL-C and with of with of statins changes in HDL-C and is changes in of of changes in statins HDL-C and was of in increases in of HDL-C with of with concentration of HDL-C of of statins on of and of atorvastatin, and of atorvastatin, and on and in patients with of and of in of effects on cholesterol and cholesterol with in patients with with simvastatin in patients with and of with and simvastatin in patients with in of statins on of in cholesterol using of statins on and in statins concentration of HDL-C and is and is concentration of and of cholesterol an of statin-induced in HDL-C and of 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in patients with in of statins on of in cholesterol using of statins on and in The statins concentration of HDL-C and is and is concentration of and of cholesterol an of statin-induced in HDL-C and of cholesterol have been of decreases in of and of atorvastatin, is decreases in of and The in HDL-C with is in of in statin-induced increases in statins HDL-C is statin-induced of of simvastatin on cholesterol and in effects of simvastatin and on and in of in of HDL The of on and of with concentration of HDL-C and of in randomized The is statins have effects HDL-C raising of statin-induced of HDL-C between and in between effects of HDL-C with different of of is have and is HDL-C of HDL of in with of in HDL-C and of and and been effects of simvastatin and of HDL in patients with and of HDL-C effects of and atorvastatin, predictors of both and of The was of an been in with cholesterol with effects of and of of on cholesterol in patients of in of patients with randomized of of The is is HDL-C 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