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BACKGROUND: Exosomes are small extracellular vesicles (30-150 nm in size) that play a critical role in cellular communication, transporting proteins, lipids, and nucleic acids between cells. This literature review focuses on evaluating the potential benefits and limitations of exosomes in enhancing skin health and aesthetics through indications such as skin rejuvenation, hair restoration, and pigmentation disorders. METHODS: A thorough literature search was conducted on PubMed using specific MeSH, including "exosomes," "aesthetics," "cosmetic dermatology," "skin rejuvenation," "hair growth," and "wrinkle reduction." The search was limited to free-access studies published in various countries within the last ten years (2014-2024). As a result, a total of 56 relevant references were identified and reviewed to support the discussion. RESULTS: There are currently no US Food and Drug Administration (FDA) approved exosomes. This review highlights exosomes' potential in skin rejuvenation through extracellular matrix production and matrix metalloproteinases (MMP) inhibition, as well as in hair restoration by stimulating follicle cell activity and modulating inflammation. Despite these benefits, challenges remain, including inconsistent isolation methods, source variability, and the need for clinical trials to confirm long-term safety and efficacy. The regulatory landscape is evolving, and further research is essential to meet standards before exosomes can be broadly adopted in cosmetic dermatology. CONCLUSION: While exosomes hold significant potential for non-invasive cosmetic dermatology, there are challenges that need to be addressed, including the standardization of exosome isolation and characterization, the establishment of safety profiles, and the conduct of extensive clinical trials. J Drugs Dermatol. 2025;24(1):12-18. doi:10.36849/JDD.8872.
Haykal et al. (Sun,) studied this question.