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In recent years, several cases of blindness, stroke, and skin necrosis have occurred after injection of soft tissue fillers. To avoid such complications, the author recommends using larger, blunt cannulas and epinephrine at the injection site, while avoiding the injection of large boluses of soft tissue filler in the face. (Aesthetic Surg J 2002;22:555-557.).
Sydney R. Coleman (Fri,) studied this question.