Why the study?
Is cytomegalovirus (CMV) infection associated with an autoimmune response to U1 snRNP in healthy individuals and patients with SLE?
Population
Healthy individuals and patients with systemic lupus erythematosus (SLE) or mixed connective-tissue disease
Design
Cross-sectional
Key result
Latent cytomegalovirus infection in healthy adults was associated with a significantly increased frequency of autoantibodies to ribonucleoprotein compared to uninfected individuals (84% vs 24%).
Authors
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May link latent CMV to autoantibody formation in healthy adults; hypothesis-generating and requires prospective confirmation.
Cross-Sectional (n=174)
Yes
Is cytomegalovirus (CMV) infection associated with an autoimmune response to U1 snRNP in healthy individuals and patients with SLE?
Absolute Event Rate: 84% vs 24%
p-value: p=<0.0001
CMV infection may play a role in inducing autoimmune responses to U1 snRNP in a subset of patients with systemic lupus erythematosus.
Newkirk et al. (2001) conducted a cross-sectional in Healthy adults and patients with autoimmune diseases (SLE, MCTD) (n=174). Cytomegalovirus (CMV) infection vs. CMV seronegativity was evaluated on Presence of autoantibodies to ribonucleoprotein (RNP) (p=<0.0001). Latent cytomegalovirus infection in healthy adults was associated with a significantly increased frequency of autoantibodies to ribonucleoprotein compared to uninfected individuals (84% vs 24%).