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experiments in a cisplatin-induced ototoxicity mouse model showed enhanced cochlear drug distribution, peaking at 24 hours, and significantly reduced auditory brainstem response (ABR) thresholds at 16 kHz and 32 kHz post-intratympanic injection. These findings highlight the LPNs' potential as a targeted, sustained-release delivery system for treating SNHL, offering improved efficacy and reduced systemic exposure. This study provides a foundation for clinical translation of LPN-based therapies in otoprotection.
Qi et al. (Fri,) studied this question.