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Chronic myelogenous leukemia (CML) accounts for 15% of adult leukemias. Although the median age of disease onset is 67 years, CML occurs in all age groups (Surveillance, Epidemiology, and End Results SEER statistics). In 2009, an estimated 5050 cases will be diagnosed and 470 patients will die from the disease in the United States. This translocation t(9;22) results in the head-to-tail fusion of the breakpoint cluster region (BCR) gene on chromosome 22 at band q11 and the Abelson murine leukemia (ABL) gene located
O’Brien et al. (Thu,) studied this question.