Pre-eclampsia and gestational hypertension were associated with markedly and mildly elevated central augmentation pressure and augmentation index, respectively, compared to normal pregnancy.
Observational (n=99)
No
Does radial artery applanation tonometry discriminate between normal pregnancy, gestational hypertension, and pre-eclampsia in third-trimester women?
Non-invasive applanation tonometry can discriminate between normal pregnancy, gestational hypertension, and pre-eclampsia, suggesting potential utility in predicting pre-eclampsia.
OBJECTIVE: To compare peripheral pulse pressure waveforms in normal pregnancy, gestational hypertension (GH) and pre-eclampsia (PE). DESIGN: Comparative study. SETTING: Tertiary referral teaching hospital. SAMPLE: Women with hypertensive disease in pregnancy and matched normal pregnant controls. METHODS: Women in the third trimester of pregnancy with newly developed PE (n= 27) or GH (n= 33) were studied by radial artery applanation tonometry. Values were compared with those for gestational age matched normal pregnant women (n= 39). MAIN OUTCOME MEASURES: Augmentation Index. RESULTS: Hypertension was of equal severity in PE and GH. Central augmentation pressure and augmentation index, indicating vasoconstriction, were mildly elevated in GH, but markedly elevated in PE. CONCLUSION: Non-invasive applanation tonometry discriminates among normal pregnancy, GH and PE, and may be useful to predict PE.
Spasojevic et al. (2005) conducted an observational in Pre-eclampsia and gestational hypertension (n=99). Pre-eclampsia and gestational hypertension vs. Normal pregnancy was evaluated on Augmentation Index. Pre-eclampsia and gestational hypertension were associated with markedly and mildly elevated central augmentation pressure and augmentation index, respectively, compared to normal pregnancy.
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