Transfusion of 1 unit of normal plasma in a patient with apolipoprotein C-II deficiency reduced plasma triglycerides from 1000 to 250 mg/dL within one day.
Case Report (n=1)
Does normal plasma transfusion reduce plasma triglyceride concentrations in a patient with severe hypertriglyceridemia and apolipoprotein C-II deficiency?
This case report identifies apolipoprotein C-II deficiency as a cause of severe hypertriglyceridemia, demonstrating that it can be temporarily corrected by normal plasma transfusion.
Absolute Event Rate: 250% vs 1000%
A 59-year-old man with severe hypertriglyceridemia and no post-heparin lipolytic activity was studied because of a marked fall in plasma triglyceride concentrations after a blood transfusion. An apolipoprotein activator (apolipoprotein C-II) for lipoprotein lipase could not be detected by polyacrylamide-gel electrophoresis of apoproteins, immunodiffusion of the plasma against anti-apolipoprotein CII or activation assays for lipoprotein lipase. Furthermore, the patient's triglyceride-rich lipoproteins would not serve as substrate for lipoprotein lipase. The patient had latent post-heparin lipolytic activity, which appeared after the addition of apolipoprotein CII to the post-heparin plasma. After a transfusion of 1 unit of plasma from a normal subject the patient's plasma triglycerides fell, within one day, from 1000 to 250 mg per deciliter and remained below preinfusion concentrations for six days. We conclude that this patient's hyperlipoproteinemia resulted from a deficiency of apolipoprotein C-II.
Breckenridge et al. (1978) conducted a case report in Severe hypertriglyceridemia (n=1). Plasma transfusion from a normal subject vs. Pre-infusion baseline was evaluated on Plasma triglyceride concentrations. Transfusion of 1 unit of normal plasma in a patient with apolipoprotein C-II deficiency reduced plasma triglycerides from 1000 to 250 mg/dL within one day.
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