Key result
Transfusion of 1 unit of normal plasma in a patient with apolipoprotein C-II deficiency reduced plasma triglycerides from 1000 to 250 mg/dL within one day.
Why the study?
Does normal plasma transfusion reduce plasma triglyceride concentrations in a patient with severe hypertriglyceridemia and apolipoprotein C-II deficiency?
Population
1 59-year-old man with severe hypertriglyceridemia and no post-heparin lipolytic activity.
Design
Case_report
Follow-up
6 days
Authors
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Supports plasma transfusion as potential therapy in apo C-II deficiency; leaves open its utility in other hypertriglyceridemia etiologies.
Case Report (n=1)
Does normal plasma transfusion reduce plasma triglyceride concentrations in a patient with severe hypertriglyceridemia and apolipoprotein C-II deficiency?
Absolute Event Rate: 250% vs 1000%
This case report identifies apolipoprotein C-II deficiency as a cause of severe hypertriglyceridemia, demonstrating that it can be temporarily corrected by normal plasma transfusion.
Breckenridge et al. (1978) conducted a case report in Severe hypertriglyceridemia (n=1). Plasma transfusion from a normal subject vs. Pre-infusion baseline was evaluated on Plasma triglyceride concentrations. Transfusion of 1 unit of normal plasma in a patient with apolipoprotein C-II deficiency reduced plasma triglycerides from 1000 to 250 mg/dL within one day.
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