Why the study?
Does intravenous infusion of fresh-frozen plasma improve lipoprotein profiles in a patient with homozygous familial apolipoprotein CII deficiency?
Population
Kindred with familial apolipoprotein CII deficiency, including a homozygous proband and heterozygous parents.
Design
Case_series
Follow-up
4 days
Authors
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May support acute FFP use in apo CII deficiency; hypothesis-generating and requires prospective confirmation before practice change.
Does intravenous infusion of fresh-frozen plasma improve lipoprotein profiles in a patient with homozygous familial apolipoprotein CII deficiency?
Intravenous infusion of fresh-frozen plasma provides apo CII, which acts as a cofactor for lipoprotein lipase, rapidly reducing chylomicrons and VLDL in a patient with homozygous apo CII deficiency.
Miller et al. (1981) studied this question.
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