Catalytic Enantioselective 1,6‐Conjugate Addition of Grignard Reagents to Linear Dienoates

Dual function of catalyst: Both regio- and enantioselectivity are dictated by Cu catalysis using the reversed josiphos ligand. This allows enantioselective 1,6-addition of Grignard reagents to acyclic α,β,γ,δ-unsaturated esters monosubstituted at the β and δ positions (see scheme).