November 18, 2002Infection and Immunity125 citationsOpen Access
View Full PaperPeptidoglycanN-Acetylglucosamine Deacetylase, a Putative Virulence Factor inStreptococcus pneumoniae
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Abstract
Many glucosamine residues of the pneumococcal peptidoglycan (PG) are not acetylated, which makes the PG resistant to lysozyme. A capsular type III mutant with an inactivated pgdA gene (encoding the peptidoglycan N-acetylglucosamine deacetylase A) became hypersensitive to exogenous lysozyme and showed reduced virulence in the intraperitoneal mouse model.
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