Coronary tortuosity was negatively correlated with the presence of coronary artery disease (OR 0.755) and did not significantly affect the incidence of major adverse cardiovascular events during follow-up.
Cohort (n=1,010)
No
Does the presence of coronary tortuosity affect the incidence of MACE in patients with suspected coronary artery disease?
Coronary tortuosity is a common angiographic finding that is more frequent in females and hypertensives, but it is negatively correlated with coronary atherosclerosis and does not appear to increase the risk of MACE.
Odds Ratio: 0.755 (95% CI 0.574–0.994)
Absolute Event Rate: 49.6% vs 60.7%
p-value: p=0.045
BACKGROUND: Coronary tortuosity (CT) is a common coronary angiography finding. The exact pathogenesis, clinical implication and long-term prognosis of CT are not fully understood. The purpose of this study is to investigate the clinical characteristics of CT in patients with suspected coronary artery disease (CAD) in a Chinese population. METHODS: A total of 1010 consecutive patients underwent coronary angiography with complaints of chest pain or related symptoms were included in the present study (544 male, mean age: 64±11 years). CT was defined by the finding of ≥3 bends (defined as ≥45° change in vessel direction) along main trunk of at least one artery in systole and in diastole. Patients with or without CAD were further divided into CT-positive and CT-negative groups, all patients were followed up for the incidence of major adverse cardiovascular events (MACE) for 2 to 4 years. RESULTS: The prevalence of CT was 39.1% in this patient cohort and incidence of CT was significantly higher in female patients than that in male patients (OR = 2.603, 95%CI 1.897, 3.607, P<0.001). CT was positively correlated with essential hypertension (OR = 1.533, 95%CI 1.131, 2.076, P = 0.006) and negatively correlated with CAD (OR = 0.755, 95%CI 0.574, 0.994, P = 0.045). MACE during follow up was similar between CAD patients with or without CT. CONCLUSIONS: CT is more often seen in females and positively correlated with hypertension and negatively correlated with coronary atherosclerosis.
Li et al. (Wed,) conducted a cohort in Suspected coronary artery disease (n=1,010). Coronary tortuosity vs. No coronary tortuosity was evaluated on Presence of coronary artery disease (CAD) (OR 0.755, 95% CI 0.574-0.994, p=0.045). Coronary tortuosity was negatively correlated with the presence of coronary artery disease (OR 0.755) and did not significantly affect the incidence of major adverse cardiovascular events during follow-up.