April 1, 1999Immunology and Cell Biology154 citations
View Full PaperOsteoprotegerin ligand: A common link between osteoclastogenesis, lymph node formation and lymphocyte development
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Abstract
The TNF-family molecule osteoprotegerin ligand (OPGL; also known as TRANCE, RANKL or ODF) has been identified as the osteoclast differentiation factor and a regulator of T cell-dendritic cell interactions in the immune system. Surprisingly, the same molecule was identified as a crucial factor in early lymphocyte development and lymph node organogenesis. We will discuss the role of OPGL in bone remodelling and the immune system.
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Kong et al. (Thu,) studied this question.