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Abstract A variety of techniques have been employed to investigate the penicillin-binding components of Bacillus subtilis, Bacillus cereus, Staphylococcus aureus, and Escherichia coli. Virtually all the binding sites in these organisms are located in the cell membrane. All the techniques which have been employed suggest that more than one binding component exists in each of these organisms, although S. aureus and E. coli both appear to have only a single major one. A particularly interesting observation was that in Bacillus subtilis one of the two major components which reacts with penicillin G does not react readily with cephalothin.
Suginaka et al. (Fri,) studied this question.