Key points are not available for this paper at this time.
Twenty years ago, R. Steinman and colleagues established that dendritic cells (DCs) have unique capacities to prime naive T cells and that DC maturation is the checkpoint for the initiation of adaptive immune responses (11–32). In the mid-1990s, C. Janeway pointed out the pivotal role of
Laurence Zitvogel (Mon,) studied this question.