Lower albumin-to-globulin ratio was an independent predictor of 90-day and 1-year mortality in patients with HFrEF, with moderate diagnostic value at cutoffs of <1.2 and <1.38 respectively.
Cohort (n=999)
A low albumin-to-globulin ratio serves as an independent prognostic biomarker for short- and medium-term mortality in patients with HFrEF.
AIM: Albumin-to-globulin ratio (AGR) is emerged as a marker of impaired prognosis. We determined the predictive value of AGR in patients with heart failure with reduced ejection fraction (HFrEF). METHODOLOGY: 999 patients with HFrEF were enrolled. Rates of 1-year all-cause mortality were compared between AGR quartiles (Q). Moreover, multivariate survival analysis in Cox's regression model and receiver operating characteristic analyses were performed. RESULTS: 90-day and 1-year mortality was the highest in AGR Q1. AGR was an independent predictor of 90-day and 1-year mortality. Receiver operating characteristic analysis revealed moderate diagnostic value in predicting 90-day (AGR cutoff <1.2) and 1-year (AGR cutoff <1.38) mortality. CONCLUSION: AGR had a good prognostic value and remained an independent predictor of mortality in HFrEF patients.
Niedziela et al. (Tue,) conducted a cohort in Heart failure with reduced ejection fraction (HFrEF) (n=999). Albumin-to-globulin ratio (AGR) vs. Higher AGR quartiles was evaluated on 90-day and 1-year all-cause mortality. Lower albumin-to-globulin ratio was an independent predictor of 90-day and 1-year mortality in patients with HFrEF, with moderate diagnostic value at cutoffs of <1.2 and <1.38 respectively.