Consuming a high-fat meal prior to 180 minutes of uninterrupted sitting significantly increased carotid-femoral pulse wave velocity (MD 0.59 m/s) compared to a low-fat meal.
RCT (n=13)
Single-blind (participants blinded to meal type, operator blinded to condition)
Randomized crossover design
No
Does a high-fat meal combined with prolonged sitting increase arterial stiffness in young healthy males compared to a low-fat meal combined with prolonged sitting?
Consuming a high-fat meal prior to prolonged uninterrupted sitting acutely worsens central arterial stiffness more than a low-fat meal, highlighting the combined cardiovascular risk of these behaviors.
Mean Difference: 0.59 (95% CI 0.29–0.89)
Absolute Event Rate: 0.59% vs 0.14%
p-value: p=0.02
Abstract Independently, prolonged uninterrupted sitting and the consumption of a meal high in saturated fats acutely disrupt normal cardiovascular function. Currently, the acute effects of these behaviors performed in combination on arterial stiffness, a marker of cardiovascular health, are unknown. This study sought to determine the effect of consuming a high-fat meal (Δ = 51 g fat) in conjunction with prolonged uninterrupted sitting (180 min) on measures of central and peripheral arterial stiffness. Using a randomized crossover design, 13 young healthy males consumed a high-fat (61 g) or low-fat (10 g) meal before 180 min of uninterrupted sitting. Carotid-femoral (cf) and femoral-ankle (fa) pulse wave velocity (PWV), aortic-femoral stiffness gradient (af-SG), superficial femoral PWV beta (β), and oscillometric pulse wave analysis outcomes were assessed pre and post sitting. cfPWV increased significantly more following the high-fat (mean difference MD = 0.59 m·s −1 ) meal than following the low-fat (MD = 0.2 m·s −1 ) meal, with no change in faPWV in either condition. The af-SG significantly decreased (worsened) (η p 2 = 0.569) over time in the high- and low-fat conditions (ratio = 0.1 and 0.1, respectively). Superficial femoral PWV β significantly increased over time in the high- and low-fat conditions (η p 2 = 0.321; 0.8 and 0.4 m·s −1 , respectively). Triglycerides increased over time in the high-fat trial only (η p 2 = 0.761). There were no significant changes in blood pressure. Consuming a high-fat meal prior to 180 min of uninterrupted sitting augments markers of cardiovascular disease risk more than consuming a low-fat meal prior to sitting.
Fryer et al. (Mon,) conducted a rct in Healthy (n=13). High-fat meal combined with uninterrupted sitting vs. Low-fat meal (10 g fat) combined with uninterrupted sitting was evaluated on Change in carotid-femoral pulse wave velocity (cfPWV) (MD 0.59, 95% CI 0.29-0.89, p=0.02). Consuming a high-fat meal prior to 180 minutes of uninterrupted sitting significantly increased carotid-femoral pulse wave velocity (MD 0.59 m/s) compared to a low-fat meal.