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Biofilm-associated infections due to recalcitrant bacterial pathogens pose a major challenge to global public health. Acinetobacter baumannii (A. baumannii) a multidrug-resistant bacterial pathogen, relies on biofilm formation and quorum sensing (QS) for sustained virulence and survival in the host. Here, we evaluated the anti-biofilm and anti-virulence potential of Myroxylon balsamum essential oil (M. balsamum EO) against A. baumannii (MCC-AB-07). M. balsamum EO disrupted biofilm formation, inhibited swarming motility, and increased bacterial susceptibility to oxidative stress. Our RT-qPCR investigations confirmed downregulation of key biofilm and QS genes. Additionally, M. balsamum EO resulted in improved survival of Caenorhabditis elegans following infection. Our findings indicate promising anti-biofilm and anti-virulence properties of M. balsamum EO, warranting elaborate investigations to explore its therapeutic applications and possible synergistic and complementary effects in conjunction with antibiotics.
Pathoor et al. (Thu,) studied this question.