Apolipoprotein L1 risk variants may cause kidney cell toxicity through a peroxisomal pathway of injury specifically activated under hypoxic conditions.
The commentary highlights a novel proposed mechanism involving a peroxisomal pathway under hypoxia for APOL1-mediated kidney injury.
Apolipoprotein L1 risk variants contribute to high rates of kidney disease among individuals of African ancestry. These gain-of-function variants cause toxicity to kidney cells, but the mechanism of injury is not clear. Many theories have been proposed, yet the field has not arrived at a consensus. Kim et al. make a compelling argument for a peroxisomal pathway of injury specifically activated under hypoxic conditions. Introducing cellular context reframes the debate about apolipoprotein L1 mechanism of disease.
Friedman et al. (Thu,) conducted a editorial in APOL1 kidney disease. Apolipoprotein L1 risk variants was evaluated. Apolipoprotein L1 risk variants may cause kidney cell toxicity through a peroxisomal pathway of injury specifically activated under hypoxic conditions.