Safety and efficacy of the ESC 0/1-hour algorithm for the rapid rule-out and rule-in of myocardial infarction
Safety and efficacy of the ESC 0/1-hour algorithm remain pending; leaves open its role in routine emergency triage.
Key result
The ESC 0/1-hour algorithm for the rapid rule-out and rule-in of myocardial infarction is currently under investigation, with safety and efficacy results pending.
Expert reaction lands here the moment PRESC1SE-MI reports.
PRESC1SE-MI is a large international stepped-wedge cluster randomized controlled trial enrolling nearly 68,000 emergency department patients with suspected myocardial infarction across Europe, the US, Australia, and Asia. It compares the ESC 0/1-hour high-sensitivity troponin algorithm against the standard 0/3-hour algorithm, with co-primary endpoints of safety (type 1 MI or all-cause death at 30 days) and efficacy (ED length of stay). Results are scheduled for presentation at ESC Congress 2026. Quote supply is very limited, with only pre-congress preview commentary from the ESC Congress Programme Committee chair available in the source material.
Absolute Event Rate: 0% vs 0%
Christian Eugen Mueller (Thu,) reported a other. The ESC 0/1-hour algorithm for the rapid rule-out and rule-in of myocardial infarction is currently under investigation, with safety and efficacy results pending.