PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
June 1, 1954Experimental Biology and Medicine25 citations

Administration of an Attenuated Type I Poliomyelitis Virus to Human Subjects

View Full Paper
HKHilary KoprowskiGJG. A. JervisTNThomas W. Norton

Key Points

Key points are not available for this paper at this time.

Abstract

Two human subjects who had no antibodies against Type I poliomyelitis virus were fed a mouse adapted Type I strain, and one human subject who had no antibodies against Types I and II was fed a mixture of mouse adapted Type I and Type II strains. None of the individuals showed clinical signs of illness as a result of ingestion of the virus. In the absence of viremia, all 3 excreted virus in the stools. Homologous neutralizing antibodies developed in the sera of each person. Virus passaged through the human intestinal tract maintained the very low pathogenicity for monkeys when injected intracerebrally.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Koprowski et al. (1954) studied this question.

synapsesocial.com/papers/6a9074e87b6e700e2c8a5820https://doi.org/10.3181/00379727-86-21062
Ask AI
Helpful
Bookmark
Share
View Full Paper