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August 1, 1935The Journal of Experimental Medicine25 citationsOpen Access

Isolation of Poliomyelitis Virus From the Nasopharynx

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JPJohn R. PaulJTJames D. TraskLWLeslie T. Webster

Key Result

Poliomyelitis virus was successfully recovered from the nasopharynx of a single patient with suspected abortive poliomyelitis, but not from 26 other cases or 14 contacts.

Study Design

Type

Case Report (n=41)

PICO

P
Population
41 individuals including 27 cases of suspected or abortive poliomyelitis and 14 contacts.
E
Exposure / Comparator
Virus isolation from the nasopharynx
O
Primary Outcome
Recovery of poliomyelitis virus

Abstract

A single example of mild illness diagnosed as suspected abortive poliomyelitis is described in which the virus of poliomyelitis was recovered from the nasopharynx by three different methods. Failure to recover virus from a total of twenty-six cases diagnosed as suspected or abortive poliomyelitis and fourteen contacts is also reported. The original material from the nasopharynx of the positive case proved unusually infective for the monkey, apparently even more so than are the majority of suspensions of spinal cords from fatal human cases of poliomyelitis. An explanation of this fact is not clear. The method of isolating human virus from the throat, by means of preserving the sediment of washings from this site in glycerine, has been shown to be efficient in one case for a period of 101 days.

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Cite This Study

Paul et al. (1935) conducted a case report in Poliomyelitis (n=41). Virus isolation from the nasopharynx was evaluated on Recovery of poliomyelitis virus. Poliomyelitis virus was successfully recovered from the nasopharynx of a single patient with suspected abortive poliomyelitis, but not from 26 other cases or 14 contacts.

synapsesocial.com/papers/6a93261d178cd16b0f58b851https://doi.org/10.1084/jem.62.2.245
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