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October 15, 1983BMJ956 citationsOpen Access

Thrombosis, abortion, cerebral disease, and the lupus anticoagulant.

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GHG. R. V. HughesSt. Vincent's University Hospital

Key Result

The presence of the lupus anticoagulant and anticardiolipin antibodies in patients with systemic lupus erythematosus is strongly associated with recurrent venous thrombosis, cerebral disease, and recurrent abortions.

Structured PICO

P
Population
Patients with systemic lupus erythematosus (SLE) and related disorders possessing lupus anticoagulant or anticardiolipin antibodies.

This early editorial highlights the emerging clinical syndrome (later known as antiphospholipid syndrome) linking lupus anticoagulant and anticardiolipin antibodies to thrombosis, recurrent abortion, and neurological disease.

Limitations

  • The immunological analysis is open to dispute
  • The association with neurological disease is still speculative
  • Antibodies may be epiphenomena rather than having pathogenic importance

Abstract

3 Frier

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Cite This Study

G. R. V. Hughes (1983) conducted an editorial in Systemic lupus erythematosus. Lupus anticoagulant and anticardiolipin antibodies was evaluated. The presence of the lupus anticoagulant and anticardiolipin antibodies in patients with systemic lupus erythematosus is strongly associated with recurrent venous thrombosis, cerebral disease, and recurrent abortions.

synapsesocial.com/papers/6aa1fc4d1b85e0eabc07e770https://doi.org/10.1136/bmj.287.6399.1088
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