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October 15, 1983BMJ954 citationsOpen Access

Thrombosis, abortion, cerebral disease, and the lupus anticoagulant.

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GHG. R. V. Hughes

Key Result

The presence of the lupus anticoagulant and anticardiolipin antibodies in patients with systemic lupus erythematosus is strongly associated with recurrent venous thrombosis, cerebral disease, and recurrent abortions.

Structured PICO

P
Population
Patients with systemic lupus erythematosus (SLE) and related disorders possessing lupus anticoagulant or anticardiolipin antibodies.

This early editorial highlights the emerging clinical syndrome (later known as antiphospholipid syndrome) linking lupus anticoagulant and anticardiolipin antibodies to thrombosis, recurrent abortion, and neurological disease.

Limitations

  • The immunological analysis is open to dispute
  • The association with neurological disease is still speculative
  • Antibodies may be epiphenomena rather than having pathogenic importance

Abstract

3 Frier

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Cite This Study

G. R. V. Hughes (1983) conducted an editorial in Systemic lupus erythematosus. Lupus anticoagulant and anticardiolipin antibodies was evaluated. The presence of the lupus anticoagulant and anticardiolipin antibodies in patients with systemic lupus erythematosus is strongly associated with recurrent venous thrombosis, cerebral disease, and recurrent abortions.

synapsesocial.com/papers/6aa1fc4d1b85e0eabc07e770https://doi.org/10.1136/bmj.287.6399.1088
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1ANTICARDIOLIPIN ANTIBODIES: DETECTION BY RADIOIMMUNOASSAY AND ASSOCIATION WITH THROMBOSIS IN SYSTEMIC LUPUS ERYTHEMATOSUS1983 · 1,399 citations
  2. 2Central nervous system lupus--diagnosis and treatment.1980 · 47 citations
  3. 3Polyspecificity of Monoclonal Lupus Autoantibodies Produced by Human-Human Hybridomas1983 · 451 citations
  4. 4Hypergammaglobulinemia, circulating anticoagulant, and biologic false positive Wassermann reaction; a study in two cases.1957 · 161 citations
  5. 5POSSIBLE RELATIONSHIP BETWEEN LUPUS INHIBITOR AND RECURRENT ABORTION IN YOUNG WOMEN1980 · 139 citations