November 1, 1998The Journal of Maternal-Fetal Medicine
Thrombophilia: A mechanism of disease in women with adverse pregnancy outcome and thrombotic lesions in the placenta
Why the study?
What is the frequency of laboratory abnormalities consistent with thrombophilia in women with adverse pregnancy outcomes and placental thrombotic lesions?
Population
13 women with adverse pregnancy outcome and thrombotic lesions in the placenta
Design
Cohort
Authors
Discussion
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Member takes
Implication
May warrant selective thrombophilia testing; leaves open whether screening improves outcomes.
Structured PICO
What is the frequency of laboratory abnormalities consistent with thrombophilia in women with adverse pregnancy outcomes and placental thrombotic lesions?
P
Population
13 women with adverse pregnancy outcome and thrombotic lesions in the placenta
I
Intervention
Workup for a thrombophilic state (anticardiolipin antibodies, lupus anticoagulant, protein C and antithrombin III activities, protein S total and free, activated protein C resistance ratio, and Factor V Leiden mutation)
O
Outcome
Frequency and type of laboratory abnormalities consistent with a thrombophilic statesurrogate
Mothers with adverse pregnancy outcomes and placental thrombotic lesions frequently have underlying thrombophilia, particularly Factor V Leiden mutation.
Cite This Study
Arias et al. (1998) studied this question.