David S. Siscovick works in General / Preventive / Lipids affiliated with New York Academy of Medicine.
David S. Siscovick is Senior Research Scientist at the New York Academy of Medicine and Professor Emeritus of Epidemiology and Medicine at the University of Washington. He has held prior affiliations with institutions including the University of North Carolina at Chapel Hill and others. His research focuses on cardiovascular epidemiology, nutrition, fatty acids, diabetes, and related genetic and environmental factors.
997 pubs · 111,226 cites · h-index 157
MD
University of Maryland
1976
MPH Epidemiology
University of Washington
1981
BA Psychology
University of Pennsylvania
1971
Senior Research Scientist
New York Academy of Medicine
Professor Emeritus, Epidemiology and Medicine
University of Washington
Kidney360Lidgard et al.cohort
Mediation by sphingomyelin 16:0 remains hypothesis-generating; extends prior links to multi-ethnic cohorts but requires prospective validation.
Frontiers in EndocrinologyHu et al.Cross-Sectional Study
Introduction Genetic variants that determine the vitamin D binding protein isoform (GC) are consistently associated with total serum 25(OH)D concentration in cross-sectional genome-wide association studies. Previous studies suggest GC isoforms may influence the increment of total 25(OH)D in response to vitamin D supplementation. The free serum 25(OH)D concentration may better reflect vitamin D status, but whether GC isoforms modify the effect of supplementation on free 25(OH)D requires further study. Objectives This study aimed to determine the associations between GC isoforms and the increments of total and free 25(OH)D 3 in response to vitamin D 3 supplementation among older adults. Methods Data were derived from the Multi-Ethnic Study of Atherosclerosis Individualized Response to Vitamin D Treatment (MESA INVITe) Study (NCT02925195). Participants (n = 666) were randomized 3:1 to 16 weeks of 2,000 IU of vitamin D 3 or placebo daily. Complete data from 559 participants (414 vitamin D 3 ; 145 placebo) were used for analysis. Total serum 25(OH)D 3 concentration, GC isoforms, and serum VDBP concentration were determined by LC-MS/MS. Free serum 25(OH)D 3 was measured by LC-MS/MS following sample preparation by size-exclusion separation. Additionally, an established prediction equation was used to estimate free 25(OH)D 3 from common biochemical measurements. The associations of GC isoforms with baseline, endpoint, and 16-week changes in total and free 25(OH)D 3 were modeled with linear regression. Models were adjusted for sex, age, season, body mass index, estimated glomerular filtration rate, and genetic ancestry. Results Mean age (SD) of the participants was 72 (8) y; 53% were females, 36% White, 33% Black, 18% Hispanic/Latino, and 13% Chinese. In each treatment group at both baseline and endpoint, total 25(OH)D 3 was lower among individuals carrying GC2 isoform (3 to 6 ng/mL lower per GC2 allele), whereas free 25(OH)D 3 , whether measured or calculated, did not vary according to GC isoform. Supplementation significantly increased total and free 25(OH)D 3 , but the increments of total and free 25(OH)D 3 were independent of GC isoform. Discussion At baseline and endpoint, total serum 25(OH)D 3 concentration, but not free 25(OH)D 3 , was lower among individuals with GC2 isoform. However, neither the total nor free 25(OH)D 3 response to vitamin D 3 supplementation varied according to GC isoform.
JACCIx et al.cross-sectional
Moderate chronic kidney disease is independently associated with both low and high extremes of the ankle brachial index in older adults, suggesting that lower extremity arterial stiffness and medial arterial calcification accompany early kidney dysfunction alongside traditional atherosclerosis.
Journal of the American Heart AssociationNomura et al.Original Research
Background Omega‐6 polyunsaturated fatty acids (PUFAs) have previously been associated with several peripheral artery disease (PAD) risk factors. We studied the association between individual omega‐6 PUFAs and incident PAD in a multicohort analysis. Methods This study was conducted among participants from 9 cohorts (N=137 704; PAD cases=2014) in the FORCE (Fatty Acids and Outcomes Research Consortium) who were free of clinical PAD at baseline. Omega‐6 PUFAs were measured at baseline and with a median follow‐up of 14 years. Cox proportional hazards regression analyses were conducted in individual cohorts to evaluate associations of omega‐6 PUFAs (continuous cohort‐standardized interquintile ranges [difference between the medians of the 10th and 90th omega‐6 PUFAs percentiles] and cohort‐specific quintiles) with incident clinical PAD adjusting for prespecified covariates. Inverse‐variance weighted meta‐analysis was used to calculate the combined hazard ratios (HRs) and 95% CIs. Results Linoleic acid (LA) was measured in all 9 cohorts, arachidonic acid in 8 (N=33 541; PAD cases=1766), dihomo‐γ‐LA and γ‐LA in 7 (N=29 861; PAD cases=1686), and eicosadienoic acid in 6 (N=27 538; PAD cases=1435). Only LA was associated with a lower risk of incident PAD (quintile 5 versus quintile 1: HR, 0.75 [95% CI, 0.64–0.89]; P =0.0009). Results did not differ in a statistically significant manner by age, sex, diabetes status, or smoking status. Conclusions Results suggest that the omega‐6 PUFA LA may be protective against PAD, and other omega‐6 PUFAs are not associated with PAD incidence. This is further evidence that omega‐6 PUFA—disease relationships should be evaluated by individual fatty acids rather than grouped as total omega‐6 PUFAs.
JACCNewman et al.review
This multi-agency expert workshop report establishes the scientific rationale and methodological framework for conducting randomized clinical trials of personal-level PM2.5 filtration interventions (particularly HEPA portable air cleaners) to reduce cardiovascular and pulmonary risk in susceptible populations.
General / Preventive / Lipids · University of Kentucky
The health benefits or harms that may come from the consumption of omega-6 fatty acids--especially LA, which constitutes 99% of the omega-6 fatty acids in the diet--are controversial. These two studies indicate that consuming more LA will likely lower risk for diabetes and CVD. This means that LA is good for us, not bad.
CirculationMarklund et al.
JACCDrazner et al.cohort
Increased left ventricular mass is an independent risk factor for the development of depressed left ventricular ejection fraction within 5 years.
American Journal of Clinical NutritionYoussim et al.Longitudinal Study
Longitudinal trial shows blood fatty acids predict hostility and Type-A personality traits over 10 years, suggesting health implications.
International Journal of EpidemiologyBen-Haim et al.cohort
Acute maternal stress during pregnancy is associated with increased blood pressure and decreased heart rate in adolescent offspring, with the effect modulated by the timing of exposure during pregnancy.
Electrophysiology · University of California, San Francisco
We cannot exclude the possibility that PVCs are an 'epiphenomenon' or some marker of future heart failure. However, as everyone in our study had no previous history of heart failure and had a normal left ventricle by an ultrasound of the heart, our data would appear to be quite convincing that PVCs represent an important predictor of the disease, causal or not. If indeed there is a causal relationship, this could represent a new approach to preventing heart failure from occurring in the first place.
Journal of the American College of CardiologyDukes et al.
JACCIx et al.cohort
Higher FGF23 levels are independently associated with an increased risk of all-cause death and incident heart failure in older adults, with the association being particularly strong in those with chronic kidney disease.
American Journal of PsychiatryYoussim et al.Original Research
Finds increased schizophrenia risk in offspring of Holocaust survivors, suggesting trauma timing matters.
JACCShlipak et al.Cohort Study
Cohort study reveals cystatin-C strongly predicts mortality in elderly heart failure patients, suggesting superior kidney assessment compared with creatinine.
JACCStewart et al.cross-sectional
Supports CV risk factor assessment in elderly patients with aortic sclerosis; leaves open whether modification prevents progression to stenosis.[[1]](https://www.jacc.org/doi/10.1016/j.jacc.2014.04.
JACCIx et al.cohort
High ankle brachial index is independently associated with greater left ventricular mass, suggesting it may lead to increased LV mass through nonatherosclerotic pathways such as arterial stiffness.
JACCKestenbaum et al.cohort
In older adults, vitamin D deficiency is associated with an increased risk of myocardial infarction and mortality, whereas parathyroid hormone excess is associated with an increased risk of heart failure.
JACCQian et al.meta-analysis
Reassures clinicians on dietary omega-3 safety regarding AF; leaves open causal effects of high-dose supplementation.
ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)Holmes et al.meta-analysis
Genetic findings support a causal effect of triglycerides on coronary heart disease risk, while the causal role of HDL-C remains uncertain.
PLoS ONEKim et al.cohort
Adverse cardiovascular risk factors across the reproductive lifespan, particularly cigarette smoking, are significantly associated with self-reported infertility in women.
