Gregory D. Lewis

SEP 2021PandeyJournal of the American College of Cardiology

Extracardiac mechanisms drive ~85% of exercise training VO2peak gains in older adults with HFpEF.

Conceptualizing HFpEF as a systemic, multi-organ geriatric syndrome highlights critical extra-cardiac and aging-related contributors to exercise intolerance, shifting therapeutic development toward transdisciplinary geroscience, lifestyle, and peripheral targets.

Transferrin Saturation Is a Better Predictor Than Ferritin of Metabolic and Hemodynamic Exercise Responses in HFpEF

Cohort study reveals that transferrin saturation better predicts exercise hemodynamics and survival than ferritin in HFpEF, highlighting its clinical utility.

MAY 2023BeaversJournal of Cardiac Failure

Iron Deficiency in Heart Failure: A Scientific Statement from the Heart Failure Society of America

This Heart Failure Society of America scientific statement synthesizes the definition, epidemiology, pathophysiology, and clinical trial evidence for iron repletion in heart failure, where iron deficiency affects roughly 50% of symptomatic patients.

AUG 2014LindmanJournal of the American College of Cardiology

Diabetes in HFpEF is linked to ~4.1-fold higher risk of 6-month cardiorenal hospitalization.

Diabetic HFpEF patients may warrant closer cardiorenal surveillance; leaves open whether targeted interventions modify hospitalization risk.

MAR 2025OstrominskiJAMA Cardiology

Valsartan reduces myocardial intracellular volume progression by ~5 mL/m² vs. placebo in early HCM.

Supports early valsartan in sarcomeric HCM; extends VANISH to CMR tissue remodeling.

Hearts developing primary graft dysfunction show early enrichment of senescence-associated proteomic pathways during ex vivo perfusion.

Ex vivo heart perfusion serves as a physiologic stress test that can unmask early molecular signatures of graft vulnerability, particularly senescence and apoptotic pathways, in donor hearts destined for primary graft dysfunction.

OCT 7GusehCirculation Genomic and Precision Medicine

Bioactive Lipids of Cardiorespiratory Fitness Insights From Exercise Models in Humans, Mice, and Burmese Pythons

Real-World Evaluation of Recombinant Zoster Vaccine Uptake and Outcomes in Solid Organ Transplant Recipients: A Retrospective Cohort Study

Herpes zoster incidence is increased after solid organ transplantation. We analyzed adult recipients of liver, heart, lung, kidney, pancreas or dual-organ transplants between January 2018 and December 2025. We assessed recombinant zoster vaccine uptake and the association between pre-transplant vaccination and post-transplant herpes zoster in 2595 patients. Median follow-up was 2.8 years [IQR 1.6-4.8]. Thirty-two percent of patients completed the two-dose recombinant zoster vaccine series before transplant. A total of 110 herpes zoster cases occurred. By vaccine status, incidence rates (per 1,000 person-years) were 15.4 [95%CI 12.1-19.5] in unvaccinated pre-transplant, 12.3 [95%CI 7.4-19.2] in those with one dose pre-transplant, and 8.1 [95%CI 4.9-12.7] in those with >2 doses pre-transplant. Among patients who received any post-transplant dose, 83% of herpes zoster cases occurred before vaccination. Compared with under-vaccinated patients, those who completed >2 pre-transplant doses had a 49% lower rate of herpes zoster in the post-transplant period (unadjusted HR=0.51 (0.31-0.85) p=0.009) and a 52% lower adjusted hazard in multivariable analysis (aHR 0.48 95% CI 0.29-0.81, p=0.006). Twenty-four cases of postherpetic neuralgia occurred, none in the fully vaccinated group. Recombinant zoster vaccine uptake remains suboptimal and pre-transplant series completion was associated with lower post-transplant herpes zoster incidence.

JUL 2008LewisJournal of the American College of Cardiology

Application of Metabolomics to Cardiovascular Biomarker and Pathway Discovery

Review demonstrates metabolomic profiling utility for cardiovascular biomarker discovery, suggesting small-molecule signatures illuminate complex disease pathways.

MAY 2012WeinerJournal of the American College of Cardiology

Regression of “Gray Zone” Exercise-Induced Concentric Left Ventricular Hypertrophy During Prescribed Detraining

PAWP/CO slope was significantly associated with increased all-cause mortality risk (adjusted HR 1.10; 95% CI 1.02-1.18; p=0.019), whereas peak PAWP was not (HR 1.0; p=0.870).

May inform mortality risk stratification in unexplained dyspnea; leaves open prospective validation of PAWP/CO slope over peak PAWP.

JAN 2016LewisJournal of the American College of Cardiology

Circulating indoleamine 2,3-dioxygenase-dependent tryptophan metabolites were identified as novel biomarkers inversely related to right ventricular ejection fraction and correlated with exercise PVR.

Metabolic profiling identified circulating biomarkers, particularly IDO-dependent tryptophan metabolites, that are associated with right ventricular-pulmonary vascular dysfunction.

JAN 2020HoJournal of the American College of Cardiology

Exercise pulmonary hypertension linked to ~2-fold higher risk of CV hospitalization or death.

May aid prognostic assessment in exertional dyspnea with preserved EF; leaves open whether treating exercise PH improves outcomes.