What question did this study set out to answer?

Review the principles, technological platforms, and clinical potential of metabolomic profiling for discovering cardiovascular biomarkers and characterizing altered metabolic pathways.

August 23, 2026Journal of the American College of CardiologyOpen Access

Application of Metabolomics to Cardiovascular Biomarker and Pathway Discovery

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Review the principles, technological platforms, and clinical potential of metabolomic profiling for discovering cardiovascular biomarkers and characterizing altered metabolic pathways.
Assessed high-throughput analytical profiling platforms, including mass spectrometry (coupled to gas chromatography or liquid chromatography) and proton nuclear magnetic resonance (1H-NMR) spectroscopy.
Evaluated quantitative metabolite separation techniques, limits of detection, and multivariate pattern recognition methods applied to human biofluids and tissues.
Mass spectrometry systems demonstrated detection limits spanning the nanomole to picomole and femtomole range (0.1 to 1 μM in human plasma), whereas 1H-NMR requires concentrations of 1 nanomole or higher.
The human metabolome encompasses approximately 3000 endogenous metabolites, presenting a chemically diverse yet more tractable target than the human proteome's estimated 10^6 to 10^9 protein species.

Implication

Review demonstrates metabolomic profiling utility for cardiovascular biomarker discovery, suggesting small-molecule signatures illuminate complex disease pathways.

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Cite This Study

Lewis et al. (2008) studied this question.

synapsesocial.com/papers/6a8a669d5416a23081b2e35f https://doi.org/10.1016/j.jacc.2008.03.043

Topics

Cardiovascular prevention

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Implication

Review demonstrates metabolomic profiling utility for cardiovascular biomarker discovery, suggesting small-molecule signatures illuminate complex disease pathways.

Application of Metabolomics to Cardiovascular Biomarker and Pathway Discovery

Key Points

Implication

Discussion

Cite This Study

Topics

Application of Metabolomics to Cardiovascular Biomarker and Pathway Discovery

Key Points

Implication

Discussion

Cite This Study

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