Figure S5 from Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor–Stroma Ratio and Promote Cancer Progression

Key Points

• Core finding: Apolipoprotein E drives changes in the tumor–stroma ratio, promoting cancer progression in pancreatic neuroendocrine tumors.
• Evidence shows that tip endothelial cells influence tumor recruitment of fibroblasts, playing a pivotal role in cancer dynamics.
• The research utilized cellular assays to investigate the interaction between apolipoprotein E and endothelial cells in tumor environments.
• These findings could lead to novel therapeutic strategies targeting the tumor–stroma interactions in pancreatic neuroendocrine tumors.