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August 17, 2025

A correlation study of paraoxonase-1 and GSH with renal function in Iraqi gynecological cancer

Key Points

Patients with gynecological cancer show significantly lower paraoxonase-1 and GSH levels compared to healthy controls, indicating a potential link to disease severity.
Measured differences in serum paraoxonase-1 activity and GSH levels reveal a critical decrease in cancer patients (p < 0.001), suggesting impaired defense mechanisms.
Observational analysis compares antioxidant activity across ovarian and uterine cancer patients versus healthy controls for insights into carcinogenesis risk.
Findings suggest that low paraoxonase-1 may correlate with increased cancer risk, highlighting the need for further studies on antioxidant levels.

Abstract

Paraoxonase (PON 1) is an important antioxidant enzyme that degrades lipid peroxidation and acts as a biomarker for carcinogenicity. The aim of this study was to compare the blood levels of paraoxonase-1 activity and glutathion GSH in Iraqi female cancer patients to those in healthy controls. Serum paraoxonase-1 activity and GSH levels were measured in patients with ovarian cancer (n = 40), uterine cancer (n = 40), and controls. Results: Patients exhibited significantly decreased serum paraoxonase and GSH levels compared to controls (p < 0.001).Conclusion: Low blood PON 1 activity may lead to an impaired antioxidant defense system, which is significant in carcinogenesis in people with gynecological malignancies.

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