Figure S5 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer

Key Points

• mTOR inhibition initiates ferritinophagy in HNSCC cells and patient samples, facilitating cell death.
• Experiments demonstrate that inhibiting mTOR leads to observable effects on ferritinophagy and ferroptosis.
• Analysis employs genome-wide CRISPR screening to uncover the mechanisms involved in cancer cell death under mTOR inhibition.
• Findings highlight the potential of targeting mTOR for therapeutic strategies in managing head and neck cancer.