Figure S17 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response

Key Points

• B7-H3 CAR T cells effectively controlled ependymomas in vivo, indicating therapeutic potential.
• In studies, PFA EPN xenografts showed effective control with B7-H3 CAR T cells, highlighting a promising treatment route.
• Strategies must address limitations in tumor size and immune response to maximize CAR T cell effectiveness.
• The findings emphasize the need for further investigation into optimizing CAR T cell therapies for ependymomas.