Supplemental Table S10 from Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype

Key Points

• Checkpoint immunotherapy response is impeded by cytotoxic NK cells during treatment of melanoma, emphasizing the immune-excluded phenotype's role.
• The study identifies specific marker genes linked to immune cell clustering using scRNA-seq data from mouse models, revealing underlying mechanisms.
• Cells were clustered based on gene expression profiles derived from scRNA-seq analysis, enabling a better understanding of immune responses.
• Findings highlight the challenge of utilizing checkpoint immunotherapy in melanoma due to immune exclusion factors, necessitating further research.