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September 4, 2025

Supplemental Table S10 from Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype

Joanna Poźniak Niccolò Roda Ewout Landeloos Asier Antoranz Yannick Van Herck Amber De Visscher Philip Georg Demaerel Lukas Vanwynsberghe Jeroen Declercq Christos Gkemisis Greet Bervoets No‐Joon Song Ayse Bassez Robin Browaeys Lotte Pollaris Francesca M. Bosisio Veerle Boecxstaens Yvan Saeys Diether Lambrechts Zihai Li Patrick Matthys Oliver Bechter Jean‐Christophe Marine

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Key Points

Checkpoint immunotherapy response is impeded by cytotoxic NK cells during treatment of melanoma, emphasizing the immune-excluded phenotype's role.
The study identifies specific marker genes linked to immune cell clustering using scRNA-seq data from mouse models, revealing underlying mechanisms.
Cells were clustered based on gene expression profiles derived from scRNA-seq analysis, enabling a better understanding of immune responses.
Findings highlight the challenge of utilizing checkpoint immunotherapy in melanoma due to immune exclusion factors, necessitating further research.

Implication

Study shows that cytotoxic NK cells impede response to checkpoint immunotherapy in melanoma, indicating potential treatment challenges.

Abstract

Discriminatory marker genes of clusters obtained after clustering of all immune cells from the scRNA-seq mouse data.

Discussion

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Cite This Study

Poźniak et al. (2025) studied this question.

synapsesocial.com/papers/68c18c089b7b07f3a061489b https://doi.org/10.1158/2159-8290.30050745

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplemental Table S11 from Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype2025
2Supplemental Table S4 from Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype2025
3Supplemental Table S3 from Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype2025
4Supplemental Table S2 from Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype2025
5Supplemental Table S7 from Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype2025

Supplemental Table S5 from Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype2025
Supplemental Table S6 from Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype2025
Supplemental Table S13 from Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype2025